Mutagenic activity of chloramines
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Cited by (44)
Development of benchmark datasets for text mining and sentiment analysis to accelerate regulatory literature review
2023, Regulatory Toxicology and PharmacologyCitation Excerpt :Similar to the CHE dataset, some of these references related to chlorine releasing chemicals such as chlorine dioxide that were not considered as relevant in current standard (Svecevicius et al., 2005; Itoh et al., 2001; Couri and Abdel-Rahman, 1979). Some references were inhalation or other toxicological studies on chemicals unrelated to chlorine, but probably was predicted to be relevant due to the similarity in experiment settings (Mauderly et al., 2014; Thomas et al., 1987; Traczewska et al., 2007). Another 272 references were predicted to be ‘Irrelevant’ but labeled relevant by reviewers.
Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases
2021, Pharmacology and TherapeuticsCitation Excerpt :These species are also oxidants, but less powerful than HOCl and HOBr, and react more slowly (Pattison & Davies, 2006b; Peskin & Winterbourn, 2001; Peskin & Winterbourn, 2003, 2006), though this is structure-dependent, with some species showing considerable reactivity (e.g. His chloramines (Pattison & Davies, 2005, 2006a; Peskin & Winterbourn, 2003)) whereas others are only weakly reactive. Di-halogenation can also occur to give RNCl2 and RNBr2 (Thomas, Jefferson, Bennett, & Learn, 1987), though these are uncommon in most biological situations as they require two successive reactions with the oxidant, which is unlikely in situations where the target concentration is large. The products formed on reaction of HOCl with protein side-chains are summarized in Table 5, together with information on the stability of these species, and whether these are specific to HOCl, or are also formed by other species.
Organic chloramines in chlorine-based disinfected water systems: A critical review
2017, Journal of Environmental Sciences (China)Citation Excerpt :In a recent in vitro study by Laingam et al. (2012), significant cytotoxicity and genotoxicity were observed for WIL2-NS cells (human lymphoblastoid) that were treated with in situ-formed N-chloroethanolamine, N-chloroglycine, N-chlorohistamine or N-chlorolysine at micromolar concentrations that are relevant for drinking water systems. All four of these organic chloramines have also demonstrated mutagenic effects in bacterial assays (Nakamura et al., 1993; Süssmuth, 1982; Thomas et al., 1987). Two studies of the effect of N-chloroacetamide on Chinese hamster ovary cells found that N-monochloroacetamide was cytotoxic but not genotoxic (Kimura et al., 2015), while N,2-dichloroacetamide was both cytotoxic and genotoxic, and more potent than N-monochloroacetamide (Kimura et al., 2015).
Genotoxicity induced by water and sediment samples from a river under the influence of brewery effluent
2017, ChemosphereCitation Excerpt :Concerning the Salmonella/microsome assay, similarly to our findings, Vargas et al. (2001) and Tagliari et al. (2004) have not shown positive results for the samples of surface water from the Sinos and Feitoria Rivers with various sources of industrial pollution (tributaries of Jacuí River); but in sediment samples it was possible to identify an indication of mutagenicity in the TA97a strain without the metabolizing fraction. This strain is able to detect frameshift mutations (Levin et al., 1982), and has been used to identify mutagenicity of PAHs and metals that act directly on DNA (Maron and Ames, 1983; Thomas et al., 1987; Flowers-Geary et al., 1996). The results obtained with S. typhimurium led to the use of tests with mammalian line V79 cell without metabolizing.
Dechlorination in Wastewater Treatment Processes
2017, Current Developments in Biotechnology and Bioengineering: Biological Treatment of Industrial EffluentsPotential carcinogenic hazards of non-regulated disinfection by-products: Haloquinones, halo-cyclopentene and cyclohexene derivatives, N-halamines, halonitriles, and heterocyclic amines
2011, ToxicologyCitation Excerpt :However, no surveys of individual organic N-chloramines appear in the literature. A search of the literature revealed a very limited toxicological data, primarily in the form of mutagenicity assays of N-chloramines of α-amino acids (Thomas et al., 1987). In Salmonella TA100, the dichloramines of histamine, ethanolamine, and putrescine were most potent, whereas histamine was most active among the monochloramine derivatives.