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Capsaicin and primary afferent neurons: From basic science to human therapy?

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References (93)

  • P. Geppetti et al.

    Neurochemical evidence for the activation of the ‘efferent’ function of capsaicin-sensitive nerves by lowering of the pH in the guinea-pig urinary bladder

    Neurosci. Lett.

    (1990)
  • P. Geppetti et al.

    Bradykinin-induced release of CGRP from capsaicin-sensitive nerves in guinea-pig atria: mechanism of action and calcium requirements

    Neuroscience

    (1990)
  • S. Giuliani et al.

    Opioid receptors and prejunctional modulation of capsaicin-sensitive sensory nerves in guinea-pig left atrium

    Gen. Pharmacol.

    (1990)
  • R. Hakanson et al.

    Multiple tachykinin pools in sensory nerve fibres in the rabbit iris

    Neuroscience

    (1987)
  • A.D. Hoyes et al.

    Degeneration of axons in the ureteric and duodenal nerve plexuses of the adult rat following in vivo treatment with capsaicin

    Neurosci. Lett.

    (1981)
  • P. Holzer

    Local effector function of capsaicin-sensitive sensory nerve endings, involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides

    Neuroscience

    (1988)
  • G. Jancso' et al.

    Neurotoxin-induced nerve cell degeneration: possible involvement of calcium

    Brain Res.

    (1984)
  • G. Jancso' et al.

    Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in adult rat

    Neurosci. Lett.

    (1985)
  • J.G. Jin et al.

    Ruthenium red prevents capsaicin-induced neurotoxic action on sensory fibers of the guinea-pig ileum

    Neurosci. Lett.

    (1989)
  • H. Juan

    Nicotinic nociceptors on perivascular sensory nerve endings

    Pain

    (1982)
  • Z. Khalil et al.

    Involvement of capsaicin-sensitive afferent nerve fibres in serotonin induced plasma extravasation and vasodilatation in rat skin

    Neurosci. Lett.

    (1989)
  • J.R. Lemos et al.

    Two types of calcium channels coexist in peptide-releasing vertebrate nerve terminals

    Neuron

    (1989)
  • C.A. Maggi et al.

    Which mechanisms account for the sensory neuron blocking action of capsaicin on primary afferents in the rat urinary bladder?

    Neurosci. Lett.

    (1990)
  • C.A. Maggi et al.

    Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans

    J. Urol.

    (1989)
  • C.A. Maggi et al.

    Topical versus systemic capsaicin densensitization, specific and unspecific effects as indicated by modification of micturition reflex in rats

    Neuroscience

    (1989)
  • C.A. Maggi et al.

    The sensory-efferent function of capsaicin-sensitive nerves

    Gen. Pharmacol.

    (1988)
  • C.A. Maggi et al.

    Evidence for two independent modes of activation of the ‘efferent’ function of capsaicin-sensitive nerves

    Eur. J. Pharmacol.

    (1988)
  • C.A. Maggi et al.

    The ‘efferent’ function of capsaicin-sensitive nerves, ruthenium red discriminates between different mechanisms of activation

    Eur. J. Pharmacol.

    (1989)
  • C.A. Maggi et al.

    Protective action of ruthenium red toward capsaicin desensitization of sensory fibers

    Neurosci. Lett.

    (1988)
  • C.A. Maggi et al.

    Similarities and differences in the action of resiniferatoxin and capsaicin on central and peripheral endings of primary sensory neurons

    Neuroscience

    (1990)
  • C.A. Maggi et al.

    The contribution of capsaicin-sensitive innervation to activation of the spinal vesico-vesical reflex in rats, relationship between substance P levels in the urinary bladder and the sensory-efferent function of capsaicin-sensitive sensory neurons

    Brain Res.

    (1987)
  • C.A. Maggi et al.

    Involvement of a peripheral site of action in the early phase of neuropeptide depletion following capsaicin desensitization

    Brain Res.

    (1987)
  • C.A. Maggi et al.

    The effect of calcium free medium and nifedipine on the release of substance P-like immunoreactivity and contractions induced by capsaicin in the isolated guinea-pig and rat bladder

    Gen. Pharmacol.

    (1989)
  • C.A. Maggi et al.

    The antagonism by Ruthenium Red of the actions of capsaicin on the peripheral terminals of sensory neurons: further studies

    Eur. J. Pharmacol.

    (1988)
  • C.A. Maggi et al.

    Calcium and capsaicin-induced substance P release from peripheral terminals of capsaicin-sensitive sensory neurons

    Regul. Pept.

    (1988)
  • C.A. Maggi et al.

    Neurochemical evidence for the involvement of N-type calcium channels in transmitter secretion from peripheral endings of sensory nerves in guinea-pigs

    Neurosci. Lett.

    (1990)
  • S. Manzini et al.

    Capsaicin desensitization protects from antigen-induced bronchospasm in conscious guinea-pigs

    Eur. J. Pharmacol.

    (1987)
  • S. Marabini et al.

    Effect of topical nasal treatment with capsaicin in vasomotor rhinitis

    Regul. Pept.

    (1988)
  • M.T. McCusker et al.

    Effect of topical capsaicin on the cutaneous responses to inflammatory mediators and to antigen in man

    J. Allergy Clin. Immunol.

    (1989)
  • M.R. Plummer et al.

    Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons

    Neuron

    (1989)
  • P. Santicioli et al.

    Exposure to calcium free medium protects sensory fibers by capsaicin desensitization

    Neurosci. Lett.

    (1987)
  • A. Saria et al.

    Beneficial effect of topically applied capsaicin in the treatment of hyperreactive neuropathy

    Regul. Pept.

    (1988)
  • A. Szallasi et al.

    Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent of red pepper

    Neuroscience

    (1989)
  • A. Szallasi et al.

    Specific binding of resiniferatoxin, an ultrapotent capsaicin analog by dorsal root ganglion membranes

    Brain Res.

    (1990)
  • M. Takaki et al.

    Ruthenium red antagonism of the effect of capsaicin on the motility of the isolated guinea-pig ileum

    Eur. J. Pharmacol.

    (1989)
  • J. Winter

    Characterization of capsaicin-sensitive neurones in adult rat dorsal root ganglion cultures

    Neurosci. Lett.

    (1987)

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