Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue☆
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Review article: Mucosa-associated lymphoid tissue (MALT)-type lymphoma of ocular adnexa. Biology and treatment
2016, Critical Reviews in Oncology/HematologyFunctional copy number changes in Sézary syndrome: toward an integrated molecular cytogenetic map III
2008, Cancer Genetics and CytogeneticsCitation Excerpt :Intriguingly, in this study, the gene cluster of copy number losses at 1p36.33p22.1, which separate SS from NC, also contains LCK, suggesting it may have a potentially functional role in the pathogenesis of SS. The BCL10 gene, which was identified by its translocation in mucosa-associated lymphoid tissue lymphoma [45,46], encodes a predicted protein of 233 amino acids and is a cellular homolog of the equine herpesvirus-2 gene (E10), both of which contain an amino-terminal caspase recruitment domain homologous to that found in several apoptotic molecules, and BCL10 was found to be expressed as a 4.2-kilobase transcript in all normal and malignant tissues examined (http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id = 603517). In addition, a previous immunohistochemistry study has demonstrated aberrant BCL10 protein expression in nasal NK/T-cell lymphoma [47].
Atlas of Head and Neck Pathology, Fourth Edition
2023, Atlas of Head and Neck Pathology, Fourth EditionGastric Neoplastic Conditions: Lymphoid Lesions of the Stomach
2021, Gastrointestinal Pathology: Correlative Endoscopic and Histologic Assessment
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This project was supported by the Sir Jules Thorn Charitable Trust and The Cancer Research Campaign.