p75 and Trk: A two-receptor system

doi:10.1016/0166-2236(95)93922-K

Trends in Neurosciences

Volume 18, Issue 7, July 1995, Pages 321-326

https://doi.org/10.1016/0166-2236(95)93922-K Get rights and content

Abstract

The neurotrophin family of survival factors is distinguished by a unique receptor-signaling system that is composed of two transmembrane receptor proteins. Nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 (NT-3) and NT-4/5 share similar protein structures and biological functions and interact with two different types of cell-surface proteins, the Trk family of receptor tyrosine kinases, and the p75, or low-affinity neurotrophin receptor. An important question is whether a dual receptor system is necessary for neurotrophin action. Evidence indicates that co-expression of the two genes for the p75 receptor and the Trk NGF receptor can potentially lead to greater responsiveness to NGF, and suggests additional levels of regulation for the family of neurotrophin factors.

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Trends in Neurosciences

p75 and Trk: A two-receptor system

Abstract

Trends Neurosci.

Neuron

Neuron

Neuron

J. Biol. Chem.

J. Biol. Chem.

Cell

Neuron

Neuron

J. Biol. Chem.

Neuron

Neuron

Cell

Neuron

Cell

Cell

Neuron