Neuropeptide modification of chloride secretion in guinea pig distal colon
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The galanin peptide family: Receptor pharmacology, pleiotropic biological actions, and implications in health and disease
2007, Pharmacology and TherapeuticsActions of galanin on neurotransmission in the submucous plexus of guinea pig small intestine
2003, European Journal of PharmacologyPeptide YY as a growth factor for intestinal epithelium
2002, PeptidesCitation Excerpt :In order for PYY to be able to exert a biological effect directly on a cell, that cell must express cell surface receptors that specifically bind PYY. Studies using whole gut tissue or stripped mucosa preparations showed that PYY or NPY could inhibit short circuit current or apical chloride secretion in a variety of species including the rabbit [6,21,22,34], rat [16,60], guinea pig [49], and human [50]. However, it was not possible to tell whether PYY or NPY had direct effects on the epithelial cells, consistent with epithelial cell expression of Y receptors, or whether the PYY effects were indirectly exerted by intervening neurotransmitter or other gut peptide networks included in the tissue preparation (even if PYY/NPY responses persisted after tetrodotoxin administration).