review
CD14: Cell surface receptor and differentiation marker

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Abstract

In the past, CD14 has been viewed simply as a useful marker molecule for monocytes and macrophages. Now, new findings on its role in binding of LPS-LBP complexes and in signal transduction have engendered renewed interest in the properties of CD14. Here, CD14 function, its expression in different cell types and the regulation of expression, including the generation of soluble CD14, are described, and the diagnostic value of CD14 in various diseases is discussed.

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  • Cited by (0)

    1

    H.W.L. Ziegler-Heitbrock is supported by Deutsche Forschungsgemeinschaft (SFB 217), by Wilhelm Sander Stiftung, and by Forschingsrat Rauchen und Gesundheir.

    2

    R.J. Ulevitch is supported by National Institutes of Health Grants AI-15136, GM-37696 and GM-28485.

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