Elsevier

Journal of Hepatology

Volume 22, Issue 1, January 1995, Pages 71-77
Journal of Hepatology

Liver injury related to amoxycillin-clavulanic acid: interlobular bile-duct lesions and extrahepatic manifestations

https://doi.org/10.1016/0168-8278(95)80262-2Get rights and content

Abstract

We report eight cases of liver injury related to amoxycillin-clavulanate. Liver biopsy performed in seven patients revealed varying degrees of injury to interlobular bile ducts in all cases. Lesions included irregularity of the nuclei, vacuolization of the cytoplasm, lymphocytic infiltration, destruction and endothelialization of the bile duct epithelium. Ductopenia was not observed. In two patients liver injury was accompanied by prominent extrahepatic manifestations (acute interstitial nephritis in one and acute lacrimal gland inflammation and sialadenitis with prolonged xerostomia in the other). We conclude that interlobular bile-duct lesions of varying severity are a common feature in liver injury related to amoxycillin-clavulanate. Side effects of the drug include acute interstitial nephritis and sialadenitis.

References (34)

  • D Larrey et al.

    Drug-induced cholestasis

    Baillieres Clin Gastroenterol

    (1988)
  • D Diaz et al.

    Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450

    Gastroenterology

    (1990)
  • HC Neu et al.

    Clavulanic acid, a novel inhibitor of β-lactamases

    Antimicrob Agents Chemother

    (1978)
  • JE Schneider et al.

    Cholestatic hepatitis after therapy with amoxicillin/clavulanate potassium

    NY State J Med

    (1989)
  • JF Dowsett et al.

    Amoxycillin/clavulanic acid (Augmentin)-induced intrahepatic cholestasis

    Dig Dis Sci

    (1989)
  • BHCh Stricker et al.

    Cholestatic hepatitis due to antibacterial combination of amoxicillin and clavulanic acid (Augmentin)

    Dig Dis Sci

    (1989)
  • G Pelletier et al.

    Hépatite cholestatique probablement due à l'association d'amoxicilline et d'acide clavulanique

    Gastroenterol Clin Biol

    (1990)
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