Matrilysin is associated with progression of colorectal tumor
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Cited by (73)
Matrix metalloproteinase-7 induces homotypic tumor cell aggregation via proteolytic cleavage of the membranebound kunitz-type inhibitor HAI-1
2017, Journal of Biological ChemistryCitation Excerpt :MMP-7 is one of a few MMPs that are overexpressed by carcinoma cells rather than stromal cells (5, 6). Among more than 20 MMPs, MMP-7 appears to be one of the most important MMPs in cancer metastasis, because expression of this MMP is correlated well with tumor malignancy and metastasis, especially with liver metastasis of colon cancers (7, 8). Our previous study demonstrated that MMP-7 binds to cell-surface cholesterol sulfate (CS) and acts as a membrane-associated protease, and the treatment of human colon carcinoma cells with active MMP-7 in vitro induces cell aggregation by cleaving cell-surface proteins (9).
MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas
2015, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyExpression and activity levels of matrix metalloproteinase-7 and in situ localization of caseinolytic activity in colorectal cancer
2014, Clinical BiochemistryCitation Excerpt :Itoh et al. showed that the enzyme activity of MMP-7 was higher in colorectal cancer tissues compared with normal tissues [33]. Ishikawa et al., as well as a result of experiments made by Yamamoto et al., asserted that the activity of MMP-7 is lower in adenomas than in cancer tissues [34,35]. The specific localization of proteolytic activity in tissue sections may provide important additional information about various physiological and pathological conditions.
Cholesterol sulfate alters substrate preference of matrix metalloproteinase-7 and promotes degradations of pericellular laminin-332 and fibronectin
2010, Journal of Biological ChemistryCitation Excerpt :Although various MMPs are overexpressed both in stromal and tumor cells in cancer tissues, MMP-7 has been detected specifically in tumor cells but not in stromal cells (12). Expression of MMP-7 is correlated well with malignancy and metastasis of cancers, especially in liver metastasis of colon cancer (13). MMP-7 also has physiological roles besides the pathological roles; the data from the MMP-7-deficient mice suggest that this protease is responsible for the activation of prodefensins and thereby participates in innate host defense (14).
Identification of amino acid residues of matrix metalloproteinase-7 essential for binding to cholesterol sulfate
2008, Journal of Biological ChemistryHuman leukocyte elastase counteracts matrix metalloproteinase-7 induced apoptosis resistance of tumor cells
2008, Cancer LettersCitation Excerpt :Matrix metalloproteinase-7 (MMP-7/Matrilysin) belongs to the minimal domain structural class of MMPs whose enhanced expression in tumors has been demonstrated [8,9]. Expression of MMP-7 in tumors is associated with an aggressive malignant phenotype and poor prognosis [10–12]. Mouse tumor models support these findings and have shown that MMP-7 plays a role in early tumor progression [13].