Journal of Pharmaceutical and Biomedical Analysis
Simultaneous determination of 5-aminosalicylic acid, acetyl-5-aminosalicylic acid and 2,5-dihydroxybenzoic acid in endoscopie intestinal biopsy samples in humans by high-performance liquid chromatography with electrochemical detection
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2022, Journal of Molecular LiquidsWS<inf>2</inf> hierarchical nanoflowers on rGO with enhanced electrochemical performance for sensitive and selective detection of mesalazine in real sample analysis
2021, Colloids and Surfaces A: Physicochemical and Engineering AspectsCitation Excerpt :Consequently, the necessity for clinical and pharmacological studies needs selective and sensitive analytical performances for the determination of drugs, particularly in several real biological fluids and also in environmental discharges. Several common analytical techniques are used for the determination of MZ in many biological matrices and pharmaceutical dosages such as high-performance liquid chromatography combined with UV [8,9], spectrophotometry [10], electrochemical detection [11], micellar electro-kinetic chromatography [12], fluorescence spectroscopy [13], liquid chromatography [14], capillary electrophoresis [15], automated chemiluminescence [16] and liquid chromatography-mass spectrometry [17]. These chromatographic and spectrophotometric techniques require sample preparation, which needs expensive equipment, laborious, and time-consuming are considered to be a barrier towards MZ analysis.
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2021, Journal of Molecular LiquidsCitation Excerpt :Mesalazine (mesalamine, 5-aminosalicylic acid, Fig. 1) is an anti-inflammatory medicine which is considered as a potential treatment for Crohn's disease and non-specific ulcerative colitis [1]. It is also regarded as a potent scavenger of reactive species of oxygen which involves an impressing role in the inhibition of antibody synthesis, inhibition of cyclooxygenase and lipoxygenase pathway, and pathogenesis of inflammatory bowel disease [2,3]. As mesalazine belongs to class IV of the biopharmaceutics classification system, it shows low permeability and low aqueous solubility [4], improving its solubility leads to a high bioavailability, and low side effects.
A laser monitoring technique for determination of mesalazine solubility in propylene glycol and ethanol mixtures at various temperatures
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2020, Journal of Molecular LiquidsCitation Excerpt :Mesalazine (mesalamine, 5-aminosalicylic acid, Fig. 1) as an anti-inflammatory drug is prescribed for the non-specific ulcerative colitis and Crohn's disease [1,2]. It plays a significant role in blocking the production of prostaglandins and leukotrienes, inhibiting adenosine-induces secretion and antibody synthesis, and scavenging reactive oxygen metabolites [3,4]. Mesalazine is reported to be the most important intermediate drug for some azo drugs synthesis [5].