The structure and regulation of tight junctions

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Abstract

Tight junctions create a paracellular barrier between both epithelial and endothelial cells. Recent advances have helped define their molecular composition and regulation. Studies in cultured cell lines provide new insights into how assembly and barrier properties may be controlled by signal transduction cascades.

Abbreviations

dgl-discs-large
diC8-1,2-dicylglycerol
MLCK
myosin light chain kinase
PKC
protein kinase C
PLC
phospholipase C

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