PaperPrognostic significance of pS2 protein expression in pulmonary adenocarcinoma
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Trefoil factors (TFFs) are increased in bronchioalveolar lavage fluid from patients with chronic obstructive lung disease (COPD)
2015, PeptidesCitation Excerpt :Forty percent of small cell lung cancers and carcinoid lung tumors have positive TFF1 immunostaining [46]. Expression of TFF1 by a pulmonary tumor is associated with a poor prognosis, possibly linked to increased expression of CA125 and decreased expression of the EGF-receptor [11]. TFF1 is elevated in serum in advanced stages of adenocarcinomas and bronchoalveolar carcinomas and it is normalized after removal of the tumor [12].
Are trefoil factors oncogenic?
2008, Trends in Endocrinology and MetabolismCitation Excerpt :TFF expression has been described in a variety of other cancers. The serum level of TFF1 is increased in patients with lung adenocarcinoma and reduced after tumour resection [66], and patients with TFF1 protein-positive pulmonary adenocarcinomas had a much worse prognosis than those with TFF1-negative adenocarcinomas [67]. TFF1, TFF2 and TFF3 mRNA expression has been associated with pancreatic cancer [3,6,68,69], with all three family members identified as the most markedly upregulated genes in intraductal papillary-mucinous tumours of the pancreas [3,6].
CA125 cytosolic levels in lung adenocarcinomas. New biological aspects
2005, Revista Espanola de Medicina NuclearCytosolic pS2 levels in 154 non small cell lung carcinomas. Correlation with other clinical and biological parameters
2002, Revista Espanola de Medicina NuclearThe pS2/TFF1 trefoil factor, from basic research to clinical applications
1998, Biochimica et Biophysica Acta - Reviews on Cancer