ReviewThe Role of Cytokines in the Pathogenesis of Acute Pancreatitis
Section snippets
Historical Perspective
Many research efforts during the past several decades have attempted to attenuate pancreatitis severity through inhibiting the deranged intracellular processes that occur within the acinar cell during AP. Investigators felt that identifying the initiating event that results in intracellular enzyme activation would lead to appropriate clinical therapies.1, 5, 6 This approach has had nominal success, however, and the initiating event in this cascade continues to elude detection. Similarly, a
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