Alimentary TractHelicobacter pylori infection among offspring of patients with stomach cancer☆,☆☆
Section snippets
Study design
Our analysis is based on a substudy of the German National Health and Nutrition Survey that was carried out in the western part of Germany in 1987-1988 (VERA-Study, Verbundstudie Ernährungserhebung und Risikofaktoren Analytik). Details of the study design have been reported previously.13 Briefly, a 3-stage (electorial districts, households, individuals) stratified probability sample was drawn from the noninstitutionalized adult population (≥18 years) of German nationality. With a participation
Results
Overall, 39 of 1351 subjects (2.9%) reported a history of stomach cancer among either of their parents, and 291 (21.5%) subjects reported a parental history of another type of cancer.
As shown in Table 1, median age was 48 years, and 56% of subjects were female.
Empty Cell History of cancer among parents Empty Cell Empty Cell Stomach cancer (n = 39) Other cancer (n = 291) No cancer (n = 1021) Total (n = 1351) Age (yr) Median 56 50 47 48 Interquartile range 47-66 41-61
Discussion
In this large population-based study, offspring of patients with stomach cancer had a clearly increased prevalence of H. pylori infection as determined by an extensively evaluated commercial IgG enzyme-linked immunosorbent assay.14 The association of a parental history of cancer with H. pylori infection among the offspring was specific for stomach cancer, and it was particularly pronounced among younger study participants. These results support the hypothesis that familial aggregation of
Acknowledgements
The authors are responsible for the content of this publication.
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2017, Clinical Gastroenterology and HepatologyCitation Excerpt :The medical history should also explore other risk factors including GC among relatives. Several Asian and Western studies have reported higher prevalence of both H pylori infection and precancerous lesions among first-degree relatives of GC patients than among controls.41,42 This may be related to several factors including common environment, a genetically determined increase in susceptibility to H pylori,43 the transmission of more pathogenic H pylori strains within a family,44 or enhanced chronic active gastritis related to a proinflammatory genotype.
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Address requests for reprints to: Hermann Brenner, M.D., Department of Epidemiology, University of Ulm, Helmholtzstrasse 22, D-89081 Ulm, Germany. fax: (49) 731-5031069.
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Supported in part by the German Federal Ministry and Technology grants 704752, 704754, and 704766 and by a grant from the “Deutsche Herzhilfe.”