Interleukin 10 modulates ion transport in rat small intestine
References (0)
Cited by (33)
Intestinal barrier function: Molecular regulation and disease pathogenesis
2009, Journal of Allergy and Clinical ImmunologyCitation Excerpt :The anti-inflammatory cytokine IL-10 has also been shown to regulate intestinal barrier function.48,49 Stimulation of ileal segments from Sprague-Dawley rats with IL-10 enhanced intestinal electroneutral sodium and chloride absorption and inhibited stimulated chloride secretion.113 In addition, treatment of T84 epithelial cell monolayers with IL-10 blocked IFN-γ–induced epithelial permeability.114
Effect of Ethanol Extracts of Three Chinese Medicinal Plants with Anti-diarrheal Properties on Ion Transport of the Rat Intestinal Epithelia
2004, Journal of Pharmacological SciencesNecrotizing enterocolitis and hematopoietic cytokines
2000, Clinics in PerinatologyCitation Excerpt :Some of the specific effects of increased IL-10 that may contribute to decreasing bowel injury include decreasing the secretion of other inflammatory cytokines69; decreasing neutrophil accumulation; downregulating mucosal T-cell activation; decreasing metalloproteinase, collagenase, and stromelysin-1 production67; and preventing the loss of glycosaminoglycans.104 IL-10 also enhances intestinal sodium and chloride absorption, inhibits stimulated chloride secretion, and under some secretory conditions stimulates bicarbonate secretion.74 It has been speculated that patients who suffer inflammatory mediated bowel injury may have a deficiency of anti-inflammatory constituents of the bowel wall or an imbalance between local production of anti-inflammatory IL-10 and proinflammatory cytokines, such as IL-1, in the lamina propria compartment.5
Diet, food components and the intestinal barrier
2017, Nutrition Bulletin