Glutamine depletion and increased gut permeability in nonanorectic, non-weight-losing tumor-bearing rats
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Absence of post-prandial gut anabolism after intake of a low quality protein meal
2012, Clinical NutritionOral glutamine supplementation during preoperative radiochemotherapy in patients with rectal cancer: A randomised double blinded, placebo controlled pilot study
2011, Clinical NutritionCitation Excerpt :They concluded that glutamine deficiency didn’t affect tumour growth but it contributed to the development of impaired physiological functions such as disturbed mucosal integrity and diminished immune competence.7 Studies on transport of amino acids between organs in animals with cancer also suggested that presence of cancer induces gut dysfunction and increases glutamine disposal, leading to disturbances in the integrity of the gut.8–10 In addition, exposure of abdominal region to ionizing radiation during radiotherapy in itself causes mucosal damage, intestinal inflammation and dysfunction.11
The 2007 ESPEN Sir David Cuthbertson Lecture: Amino acids between and within organs. The glutamate-glutamine-citrulline-arginine pathway
2008, Clinical NutritionCitation Excerpt :We showed that compromised gut protein synthesis during isoleucine-free protein diets (“blood meals”) could be restored by intravenous isoleucine infusion.9 After this initial period, our research focused more on glutamine metabolism and glutamine-rich nutritional support.10–13 Furthermore, we expanded our research towards arginine (and related citrulline) metabolism and arginine-rich nutritional support,14–16 and examined the potentials of arginine supplementation in patients with sepsis.17
Effects of glutamine on adhesion molecule expression and leukocyte transmigration in endothelial cells exposed to arsenic
2005, Journal of Nutritional Biochemistry