Alimentary TractIn vivo butyrate metabolism and colonic permeability in extensive ulcerative colitis☆,☆☆
Section snippets
Subjects
All controls were healthy volunteers without gastrointestinal complaints who did not use medication (except oral contraceptives).
All patients had extensive UC reaching at least to the splenic flexure. All patients with active disease were hospitalized, and 22 of 25 patients with active UC received intravenous steroids, 7 in combination with immunosuppressants (Imuran [Burroughs Wellcome, Research Triangle Park, NC] or cyclosporine); 9 patients were administered mesalamine. Eleven patients were
Variable retention time
Figure 1 shows the mean (±SEM) 14CO2 % dose/h excretion between 0 and 6 hours in UC patients with active disease, in patients with inactive UC, and in healthy controls. At each time point (except at
Discussion
Butyrate is one of the SCFAs that are end products of the colonic fermentation of mainly carbohydrates. It serves as a major source of energy for the colonocytes. An impaired production of butyrate, deficient uptake, or insufficient utilization might be involved in the pathogenesis of UC. A diminished5, 6, 7 as well as a normal8, 9 butyrate metabolism of colonocytes of UC patients have been noted in vitro. The technique of colonocyte preparation and incubation are of major importance and might
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Address for requests for reprints to: Paul Rutgeerts, Department of Gastroenterology, University Hospital Leuven, Herestraat 49, B-3000 Leuven, Belgium. Fax: (32) 16-344419.
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Supported by a grant from the Danone Institute (Clinical Research Grant in Human Nutrition).