Alimentary TractThe factor V Leiden mutation increases the risk of venous thrombosis in patients with inflammatory bowel disease☆,☆☆
Section snippets
Materials and methods
The study population included 11 patients with a history of IBD and thromboembolic complications and 51 IBD controls. A review of the records from Los Angeles County–University of Southern California (LAC-USC) Medical Center Anticoagulation Clinic, the IBD clinic, and hematology consultation records identified 14 patients with IBD and a history of either arterial or venous thrombosis. Only 11 of these patients were available to perform studies for APCR and factor V Leiden. A control population
Results
The characteristics of the study populations are shown in Table 1. There were no significant differences in age or sex between the IBD patients with thrombosis and patients without thrombosis. The average age of the patients with IBD at the time of their thrombotic event was 39 years (range, 21-64 years), and the patients were studied an average of 2.5 months (range, 4 days to 36 months) after their thromboembolic event. Ulcerative colitis was the most frequent form of IBD in patients with
Discussion
Thromboembolic complications are a rare but a significant complication of IBD. The reported incidence of thrombosis in three large retrospective studies was approximately 1.3%-6.4%.1, 4, 5 However, the contribution of thromboembolic complications to patient morbidity and mortality is significant. In the study by Talbot et al.,5 23 of 92 patients (25%) with documented thromboembolic complications died during their acute episodes. Therefore, a better understanding of the mechanisms contributing
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Address requests for reprints to: Howard A. Liebman, M.D., Department of Medicine and Pathology, University of Southern California School of Medicine, Kenneth Norris Jr. Cancer Hospital, Topping Tower, Third Floor, 1441 Eastlake Avenue, Los Angeles, California 90033. e-mail: [email protected]; fax: (213) 764-0060.
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Supported in part by grant 987 F1-2 from the American Heart Association Greater Los Angeles Chapter (to H.A.L.).