Alimentary TractClinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori☆,☆☆
Section snippets
Patients
A total of 94 patients (57 male and 37 female; age, 53.3 ± 16.1 years; range, 22–85 years) with culture-proven H. pylori infection were recruited in a community hospital in Oss, The Netherlands, and underwent endoscopy before receiving anti-Helicobacter treatment. These patients were in need of anti-Helicobacter therapy, and because we normally do not treat all H. pylori–infected individuals, ulcer patients are relatively common in this patient group. The presence of ulcers was based on visual
Results
vacA, iceA, and cagA genotypes of H. pylori were analyzed in 94 patients living in The Netherlands. Thirty-four (36.2%) of these 94 patients had gastritis only and were classified as nonulcer cases. Sixty (63.8%) patients had proven peptic ulcer disease: 46 (48.9%) first or chronic duodenal ulcer disease, and 14 (14.9%) first or recurrent gastric ulcer. There was no significant difference between the mean age of patients with and without ulcers (52.9 ± 17.3 and 54.1 ± 14.1 years, respectively).
Discussion
The presence of H. pylori in the gastric mucosa leads to chronic gastritis and eventually atrophic gastritis and is associated with diseases such as peptic ulcers, gastric carcinoma, and MALT lymphoma.2, 23 However, there is a clear discrepancy between the number of infected individuals and patients with clinical symptoms. Although host and environmental factors are considered important,24, 25, 26 there is also evidence for a role of specific H. pylori genotypes. Infection with certain H. pylori
Acknowledgements
The authors thank Dr. G. J. J. M. Borsboom for his helpful suggestions and C. L. A. M. van Hoek for preparation of the LiPA strips.
References (51)
- et al.
Heterogeneous Helicobacter pylori isolates from members of a family with a history of peptic ulcer disease
Gastroenterology
(1996) - et al.
Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains
J Biol Chem
(1994) - et al.
Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration
J Biol Chem
(1995) - et al.
Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori
Gastroenterology
(1997) - et al.
Association between vacA and cagA status of Helicobacter pylori and the efficacy of a 1-day quadruple therapy
Lancet
(1997) Ecology of Helicobacter pylori in the human stomach
J Clin Invest
(1997)- et al.
Helicobacter pylori
Clin Microbiol Rev
(1997) - et al.
Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: extensive allelic diversity and recombinational population structure
J Bacteriol
(1996) - et al.
Genomic DNA fingerprinting of clinical isolates of Helicobacter pylori using short oligonucleotide probes containing repetitive sequences
J Appl Bacteriol
(1996) Intrastrain differences in Helicobacter pylori: a key question in mucosal damage?
Ann Med
(1995)
Defining Helicobacter pylori as a pathogen: strain heterogeneity and virulence
Am J Med
The clinical relevance of strain types of Helicobacter pylori
Gut
Cytotoxic activity in broth culture filtrates of Campylobacter pylori
J Med Microbiol
Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease
J Exp Med
The vacuolating cytotoxin of Helicobacter pylori
Mol Microbiol
Expanding allelic diversity of Helicobacter pylori vacA
cag, a pathogenicity island of Helicobacter pylori, encodes type I–specific and disease-associated virulence factors
Proc Natl Acad Sci USA
Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells
Mol Microbiol
Mucosal chemokines in Helicobacter pylori infection
J Physiol Pharmacol
Pathogenic diversity of Helicobacter pylori
J Gastroenterol
Expression of a novel ulcer-associated H. pylori gene, iceA , following adherence to gastric epithelial cells
Gastroenterology
Molecular cloning, a laboratory manual
Typing of HCV isolates and characterization of new (sub)types using a line probe assay
J Gen Virol
Gastric MALT lymphoma and Helicobacter pylori
Yale J Biol Med
Are there susceptible hosts to Helicobacter pylori infection?
Scand J Gastroenterol Suppl
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Address requests for reprints to: Leen-Jan van Doorn, Ph.D., Delft Diagnostic Laboratory, R. de Graafweg 7, 2625 AD, Delft, The Netherlands. e-mail: [email protected]; fax: (31) 15-2604550.
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Supported by PRAXIS XXI (to C.F.).