Alimentary TractOmeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice☆,☆☆
Section snippets
Subjects
Twenty-three healthy volunteers were studied (7 men and 16 women; mean age, 30 years; age range, 20–47 years). None had a history of gastrointestinal disease, and none had dyspepsia. H. pylori status was determined by a [14C]urea breath test, as previously described.39
Design
The study took place on 2 separate days. Subjects avoided eating leafy vegetables for 24 hours before presenting fasted on the morning of each study day. On day 1, basal samples of blood, saliva, and gastric juice were collected,
Results
Three subjects dropped out after the first study day and were excluded from the analysis. All values are expressed as medians with ranges in parentheses.
Discussion
This study indicates that pharmacologically induced profound hypochlorhydria depletes intragastric AA concentrations and increases intragastric nitrite concentrations. These changes are apparent in the fasting state but are even more marked after ingestion of nitrate. In H. pylori–positive subjects, pharmacologically induced hypochlorhydria also decreases both gastric and serum TVC concentrations.
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Cited by (0)
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Address requests for reprints to: Kenneth E. L. McColl, M.D., University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland. e-mail: [email protected]; fax: (44) 141-339-2800.
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Supported by the Scottish Home and Health Department, Scottish Office, Edinburgh, Scotland.