Original articleEvaluation of a serum IgA-class reticulin antibody test for the detection of childhood celiac disease
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Clinical usefulness of serum antibodies as biomarkers of gastrointestinal and liver diseases
2017, Digestive and Liver DiseaseCitation Excerpt :They were detected by standard indirect immunofluorescence on cryostat section of rodent tissues, stomach, liver and kidney. Although some authors reported remarkably good levels of sensitivity and specificity [33], in everyday clinical practice the results were more disappointing and they never became a test used world-wide. The era of coeliac serology kicked off in the early 1980s with the discovery of ELISA anti-gliadin antibodies (AGA) and immunofluorescent anti-endomysial antibodies (EMA) [34,35].
Celiac disease diagnosis in 2008
2008, Archives de PediatrieIL-15 drives the specific migration of CD94+ and TCR-γδ+ intraepithelial lymphocytes in organ cultures of treated celiac patients
2001, American Journal of GastroenterologyCitation Excerpt :This pathology is characterized by specific changes at the level of the small intestine with characteristic villus atrophy (2), intraepithelial lymphocytes infiltration (2), and production of anti-endomysium antibodies (4, 5). The antiendomysium antibodies have been considered to be a specific marker for disease (4–8) and reported to recognize tissue transglutaminase (9). Because gluten drives CD, simple gluten-free diet controls all the signs of this pathology.
Systematic review and meta-analysis: the incidence and prevalence of paediatric coeliac disease across Europe
2021, Alimentary Pharmacology and Therapeutics
Supported by the Emil Aaltonen Foundation.