Original articleLiver disease associated with anti-liver-kidney microsome antibody in children*
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Cited by (119)
Paediatric autoimmune hepatitis: Time to change the textbooks?
2023, Journal of HepatologyLong-term outcomes of patients with type 1 or 2 autoimmune hepatitis presenting in childhood
2023, Journal of HepatologyLong-term follow-up of children and young adults with autoimmune hepatitis treated with cyclosporine
2019, Digestive and Liver DiseaseCutting edge issues in autoimmune hepatitis
2016, Journal of AutoimmunityCitation Excerpt :Interestingly, a recent study suggests that the latter two characteristics are stronger indicators of AIH than interface hepatitis or plasma-cell rich infiltrate [89]. In some patients, however, such findings may be absent [90]. Histology is also the gold standard for evaluating the extent of fibrosis and it helps in identifying overlap syndromes as well as the possible presence of concomitant diseases, such as alcoholic and non-alcoholic fatty liver disease [91].
Seronegative autoimmune hepatitis in children: Spectrum of disorders
2016, Digestive and Liver DiseaseCitation Excerpt :The occurrence of an autoantibody-negative autoimmune hepatitis has been reported in adults [14,15] and sporadically in children [16,17], without however being recognized as a distinct entity, at least in childhood. Although the role of a previously unidentified virus(es) or of an unidentified drug responsible for the hepatitis of the children reported here cannot be excluded, there are several arguments favoring the non-viral, akin to autoimmune, origin of these seronegative hepatitides because many of the factors commonly found in children with autoantibody-positive autoimmune hepatitis were present, including: (1) a liver histology displaying portal fibrosis and interface hepatitis in more than ¾ of cases, septal fibrosis in half the cases, as well as panlobular, bridging and centrilobular necrosis, all combined with portal and lobular lymphomonocytic infiltrate, comprising plasma cells in more than half the cases [9,18–20]; (2) the normalization of aminotransferases activity and of prothrombin time within a few weeks or months under immunosuppressive therapy [11]; (3) in more than half the children, a disease of autoimmune origin combined with the hepatitis occurring either simultaneously or secondarily [2,3,13]; and (4) an autoimmune disease in family members in 40% of children [4]. Moreover, when applying the international autoimmune hepatitis score [8], 17 patients scored as definite and 21 as probable autoimmune hepatitis.
Features and Progression of Asymptomatic Autoimmune Hepatitis in Italy
2016, Clinical Gastroenterology and Hepatology
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Supported by a grant from Foundazione Anna Villa Rusconi, Varese, Italy (G.M.).