Journal of Ultrastructure Research
The ultrastructural organization of the rat exocrine pancreas: II. Centroacinar cells, intercalary and intralobular ducts
References (8)
- et al.
J. Ultrastructure Research
(1962) - et al.
J. Ultrastructure Research
(1962) Secretory Mechanism of the Digestive Glands
(1950)Sekretionsstudien am Pankreas
(1957)
Cited by (47)
Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation
2016, Developmental BiologyCitation Excerpt :In adult fish CACs are located in a terminal duct position within the lumen of the acinus – the functional unit of the exocrine pancreas. An enigmatic cell type with distinct ultrastructure (Ekholm et al., 1962; Parsons et al., 2009), CACs possess specialized morphology with long cytoplasmic extensions that line the pancreatic ducts and extend into the parenchyma (Beer et al., 2016; Leeson and Leeson, 1986; Pour, 1994). Following β-cell ablation, CACs leave their location in the acinus (Pour, 1994) before either forming new small islets or contributing to preexisting islets (Delaspre et al., 2015).
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas
2012, Developmental BiologyCitation Excerpt :Nonetheless, Notch signaling appears to be active in the adult pancreas, as evidenced by expression of its target gene Hes1 in centroacinar cells (CACs) and ducts (Kopinke et al., 2011; Miyamoto et al., 2003; Parsons et al., 2009; Stanger et al., 2005). CACs constitute the terminal element of the ductal tree and are characterized by their central position within individual acinar rosettes (Ekholm et al., 1962). These cells have been proposed to represent an adult progenitor-like cell in the pancreas and to produce new β-cells following injury (Hayashi et al., 2003; Nagasao et al., 2003) and in vitro (Rovira et al., 2010).
Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas
2009, Mechanisms of DevelopmentPten constrains centroacinar cell expansion and malignant transformation in the pancreas
2005, Cancer CellCitation Excerpt :Centroacinar cells have emerged as a candidate cell of origin based upon the persistent activation of the Notch pathway in these cells in adulthood (Miyamoto et al., 2003). Although centroacinar cells constitute the terminal cells of the ductal system and contain ultrastructural features of ductal cells (Ekholm et al., 1962), the precise lineage of centroacinar cells has not yet been elucidated. The Pten tumor suppressor gene encodes a dual activity phosphatase that is frequently mutated in human tumors (Luo et al., 2003).
Formation of ductular structures in vitro by rat pancreatic epithelial oval cells
1993, Experimental Cell Research