Histamine and spontaneous motor activity: Biphasic changes, receptors involved and participation of the striatal dopamine system
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2016, Behavioural Brain ResearchContribution of the central histaminergic transmission in the cataleptic and neuroleptic effects of haloperidol
2015, Pharmacology Biochemistry and BehaviorCitation Excerpt :Considering all the points, our observation on the influence of H2 receptor antagonist on haloperidol-induced behavioral effects seem to be promising, as the role of H2 receptor in the modulation of central dopaminergic activity, especially in basal ganglia has been already suggested. Few researchers demonstrated lack of effect of H2 receptor on dopaminergic activity (Chiavegatto et al., 1998) while some demonstrated both increased (Farzin and Attarzadeh, 2000; Liu et al., 2007; Otsuka et al., 2003) and reduced (Hamami et al., 2004) dopamine activity in the CNS after H2 receptor stimulation or antagonism. However, our experimental outcome clearly points towards a possible anti-dopaminergic like activity of histamine via H1 or H2 receptor stimulation that might be responsible for the observed potentiating effects of l-histidine on haloperidol-induced cataleptic and neuroleptic effects.
Respiratory deficits in a rat model of Parkinson's disease
2015, NeuroscienceCitation Excerpt :All behavioral tests were performed on the same day and occurred 1 day before, and 30 and 60 days after vehicle (n = 8), 6 μg (n = 8), 12 μg (n = 8) or 24 μg of 6-OHDA (n = 7). Spontaneous locomotor activity was measured as previously described (Chiavegatto et al., 1998) with minor modifications. The OF apparatus consisted of a white wooden square (100 × 100 × 38 cm) with the floor marked off in 36 squares.
The H<inf>3</inf>receptor agonist immepip does not affect l-dopa-induced abnormal involuntary movements in 6-OHDA-lesioned rats
2014, European Journal of PharmacologyCitation Excerpt :There is a high density of H3 receptors in both striatum and substantia nigra (Cumming et al., 1991; Lovenberg et al., 1999; Pillot et al., 2002a; Ryu et al., 1994, 1996) and there is evidence for alterations in the levels of histamine, the density of histaminergic innervation and the density of H3 receptors in the basal ganglia in PD and 6-OHDA-lesioned rats (Anichtchik et al., 2000, 2001; Nowak et al., 2009; Rinne et al., 2002; Ryu et al., 1994, 1996; Shan et al., 2012). Importantly, histamine and H3 receptors have been implicated in the control of motor activity (Chiavegatto et al., 1998; Nistico et al., 1980; Pillot et al., 2002b; Sakai et al., 1991; Tuomisto and Eriksson, 1980) and they may function to decrease excessive GABA and glutamate release in the basal ganglia thought to underlie dyskinesia (Gomez-Ramirez et al., 2006). In normal rats, H3 agonists can induce ipsilateral rotation when injected unilaterally into the substantia nigra.