Cell
Volume 113, Issue 7, 27 June 2003, Pages 821-823
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Metastatic Potential: Generic Predisposition of the Primary Tumor or Rare, Metastatic Variants—Or Both?

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Abstract

Metastasis is a rare event. Does it arise from rare, variant, highly metastatic cells or does a primary tumor progress to a premalignant state from which metastases arise stochastically without further changes in gene expression? Arguments and evidence have been adduced to support either position. A paper in this month's Cancer Cell (Kang et al., 2003) and other arguments instead suggest models combining features of both.

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