Elsevier

The Lancet

Volume 246, Issue 6370, 29 September 1945, Pages 397-401
The Lancet

ORIGINAL ARTICLES
ASPIRATION LIVER BIOPSY: TECHNIQUE AND DIAGNOSTIC APPLICATION

https://doi.org/10.1016/S0140-6736(45)91946-5Get rights and content

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      Liver aspirates were used since the early 1800s to treat hydatid cysts [80]. Later, this technique was adapted to sampling liver tissues, with reports of large series in 1923 from Germany [81] and in 1939 from Mount Sinai Hospital, New York [82], but biopsies were not widely used until the late 1950s, after newer techniques developed by Menghini were introduced [79] and an influential report from the United Kingdom was published in 1954 [12]. The increasing use of liver biopsies in the management of liver tumors led to sampling of a much wider array of liver masses, resulting in reports of many rare tumors and reports of rare findings in common tumors.

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      Similar results can be seen if we compare the 4 studies79–81,83 that directly evaluated the performance of KCC and MELD in the same ALF population. Liver biopsy has been an important tool to aid diagnosis of hepatic pathology for more than 70 years.88 Guidelines generally support the use of liver biopsy in situations of diagnostic doubt,89 but the role in ALF is uncertain.

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      Accurate determination of fibrosis is essential for assessing liver damage and managing treatment. Before 1970s, LB was used almost exclusively as diagnostic tool.2,3 Then serology became well-established method for diagnosis of viral hepatitis.

    • Cellular and molecular techniques

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