THE IRRITABLE BOWEL SYNDROME: A PAROXYSMAL MOTOR DISORDER
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Emotional stress responsivity of patients with IBS - a systematic review
2022, Journal of Psychosomatic ResearchCitation Excerpt :A total of 37 studies were selected for narrative synthesis. Studies were published between 1982 [12] and 2018 [13], with most of them being conducted in the United States [k = 13] [12,14–25] followed by England [k = 6] [26–31] and Germany [k = 5] [32–36]. Sample sizes ranged from 16 [29] to 349 [31] participants.
Psychophysiological Bases of Disease
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2016, The Curated Reference Collection in Neuroscience and Biobehavioral PsychologyGut memories: Towards a cognitive neurobiology of irritable bowel syndrome
2012, Neuroscience and Biobehavioral ReviewsCitation Excerpt :For example, in one of the first studies to employ a standardised stress procedure (interview) to evoke anger, greater myoelectrical activity and motor responses of the rectosigmoid as indexed by increases in spike activity and motility indices, were found in IBS patients in comparison to healthy controls (Welgan et al., 1988). Additionally, early studies also documented that in response to psychological stress, IBS patients showed abnormal motility patterns in the small bowel when compared to healthy individuals (Kumar and Wingate, 1985). Contemporary studies assessing the role of stress in IBS have focused on the functionality of the two key effector systems of the neurobiological stress response in man; the hypothalamic–pituitary–adrenal (HPA) axis and autonomic nervous system (ANS; sympathetic/parasympathetic).
Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?
2011, Brain, Behavior, and ImmunityCitation Excerpt :Activation of the stress or ‘fight or flight’ response is mediated by the sympathoadrenal medullary system, an adaptive reaction that has evolved to ensure survival of the organism. Indeed, IBS patients have higher basal levels of norepinephrine (Posserud et al., 2004) and there is an extensive literature demonstrating that IBS subjects’ exhibit exaggerated motor and sensory responses on exposure to various controlled stressors which precipitate their usual symptoms (Kellow et al., 1992; Kumar and Wingate, 1985; McKee and Quigley, 1993a,b; Simren et al., 2007). The stress response can be triggered by various environmental stimuli, such as fear, aggression, unexpected environmental changes, social isolation or other pathological conditions.
Neural Control of the Colon
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