Elsevier

The Lancet

Volume 345, Issue 8964, 17 June 1995, Pages 1525-1528
The Lancet

Article
Long-term sequelae of Helicobacter pylori gastritis

https://doi.org/10.1016/S0140-6736(95)91084-0Get rights and content

Abstract

Chronic Helicobacter pylori gastritis has been put forward as a risk factor for development of gastric mucosal atrophy and gastric cancer. The purpose of our study was to investigate the long-term effects of H pylori gastritis on the gastric mucosa. We prospectively studied 49 subjects negative for H pylori and 58 positive subjects for a mean follow-up of 11·5 years (range 10-13 years). Serum samples were obtained at the initial and follow-up visits for determination of H pylori IgG antibodies. Gastroscopies with biopsy sampling were done in all patients at both visits. Biopsy specimens were used for assessment of H pylori infection and histology. Development of atrophic gastritis and intestinal metaplasia occurred in 2 (4%) uninfected and 16 (28%) infected subjects. Regression of atrophy was noted in 4 (7%) infected subjects. Development of atrophic gastritis and intestinal metaplasia was significantly associated with H pylori infection (p=0·0014; odds ratio 9·0, 95% Cl 1·9-41·3). The proportion of atrophic gastritis in the study population showed an annual increase of 1·15% (0·5-1·8%). We conclude that H pylori infection is a significant risk factor for development of atrophic gastritis and intestinal metaplasia. Our findings support strongly the causative role of this infection in gastric carcinogenesis.

References (24)

  • N. Banatvala et al.

    The cohort effect of Helicobacter pylori

    J Infect Dis

    (1993)
  • Cited by (736)

    • Chemoprevention Against Gastric Cancer

      2021, Gastrointestinal Endoscopy Clinics of North America
    View all citing articles on Scopus
    View full text