Trends in Pharmacological Sciences
ReviewTherapeutic uses of heparin beyond its traditional role as an anticoagulant
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Fabrication of pH-sensitive magnetic metal-organic framework for controlled-release of heparin
2022, Colloids and Surfaces B: BiointerfacesCitation Excerpt :Heparin, a naturally occurring glycosaminoglycan, is traditionally used as a clinical anticoagulant and antithrombotic drug, also has antitumor, anti-inflammatory, antiviral, and other pharmacological activities [1,2]. It is widely used in treating cerebrovascular, cardiovascular, obstetric, kidney and pulmonary diseases, and cancer [3–5]. However, heparin suffers from short serum half-life, poor oral absorption, low tissue permeability, and the risk of overdose [6,7].
In situ hydrogel dressing loaded with heparin and basic fibroblast growth factor for accelerating wound healing in rat
2020, Materials Science and Engineering CpH-activatable polymeric nanodrugs enhanced tumor chemo/antiangiogenic combination therapy through improving targeting drug release
2019, Journal of Colloid and Interface ScienceCitation Excerpt :Moreover, the tumor inhibition rates of LMWH-UOA and sLMWH-UOA nanodrug were 2.04-fold and 1.52-fold than that of LMWH + UOA respectively, suggesting that LMWH-UOA and sLMWH-UOA nanodrug could further enhance the antitumor efficiency of LMWH + UOA. This might because that compared with LMWH + UOA group, both LMWH-UOA and sLMWH-UOA nanodrug could locate to tumor resulting into increased drug accumulation in tumor through EPR-effect induced passive tumor targeting ability and LMWH-mediated endocytosis [41]. More importantly, it was noted that sLMWH-UOA showed further significantly enhanced antitumor efficiency than LMWH-UOA (P < 0.01).
Dose-reduction antiangiogenic curcumin-low molecular weight heparin nanodrugs for enhanced combinational antitumor therapy
2018, European Journal of Pharmaceutical SciencesEffects of fucoidans and heparin on reactions of neutrophils induced by IL-8 and C5a
2017, Carbohydrate PolymersCitation Excerpt :Heparins are not only potent antithrombotics, but exhibit a broad spectrum of biological activities including several effects resulting in anti-inflammatory potency (Lever & Page, 2012; Tyrell, Kilfeather, & Page, 1995).