Review
Taming TNF: strategies to restrain this proinflammatory cytokine

https://doi.org/10.1016/S0167-5699(97)01118-3Get rights and content

Abstract

Recent studies have demonstrated the essential role of tumor necrosis factor a (TNF-α) in rheumatoid arthritis and Crolin's disease. This article discusses agents known to suppress the formation or activity of TNF-α, and summarizes clinical studies using anti-TNF-α antibodies.

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    The work of the authors is supported by grant En 169/2-3 of the Deutsche Forschungsgemeinschaft, grant 93.042.3 of the Wilhelm Sander-Stiftung and by a grant of the Ernst und Berta Grimmke-Stiftung.

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