CommentPertussis infection and vaccination induces Th1 cells
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2009, Journal of Pharmaceutical SciencesCitation Excerpt :Induction of the appropriate immune response (humoral vs. CMI vs. regulatory) is essential for vaccine efficacy.37, 38 For example, in the BALB/c model of leishmaniasis, an immune response dominated by IL-4 and IgG1 (i.e., Th2-biased response), in comparison to a protective Th1-biased response (IFN-γ and IgG2a), does not protect nor allow these mice to clear the infection.39–41 Furthermore, in regions of the world where tuberculosis is endemic, a large portion of the population is infected and presents with a preexisting immune response to Mycobacterium species that is usually Th2 dominant.42
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