Regular PaperIdentification of connective tissue gene transcripts in freshly isolated parenchymal, endothelial, Kupffer and fat-storing cells by Northern hybridization analysis
References (58)
- et al.
Expression of the novel extracellular matrix component tenascin in normal and diseased human liver: an immunohistochemical study
J Hepatol
(1990) - et al.
Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis
Gastroenterology
(1990) - et al.
The effects of hepatic fibrosis on Ito cell gene expression
Matrix
(1992) - et al.
Differential expression of laminin chains in hepatic lipocytes
FEBS Lett
(1991) - et al.
In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion
J Hepatol
(1989) - et al.
Isolation and characterization of Kupffer and endothelial cells from rat liver
Exp Cell Res
(1977) - et al.
Single-step method of RNA isolation by acid guanidinium thiocyanate — phenol — chloroform extraction
Anal Biochem
(1987) - et al.
Three different fibronectin mRNAs arise by alternative splicing within the coding region
Cell
(1983) - et al.
Genes for basement membrane proteins are coordinately expressed in differentiating F9 cells but not in normal adult murine tissues
Dev Biol
(1987) - et al.
Retinoids, retinoid-binding proteins, and retinyl palmitate hydrolase distributions in different types of rat liver cells
J Lipid Res
(1985)
Perisinusoidal fat-storing cells are the main vitamin A storage sites in rat liver
Exp Cell Res
(1985)
Plasma fibronectin is synthesized and secreted by hepatocytes
J Biol Chem
(1983)
Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture
Gastroenterology
(1988)
The extracellular matrix of the liver
Coll Rel Res
(1982)
Structure of the extracellular matrix in normal and fibrotic liver: collagens and glycoproteins
Semin Liver Dis
(1990)
Vitronectin in liver disorders: biochemical and immunohistochemical studies
Hepatology
(1992)
Cellular sources of noncollagenous matrix proteins: role of fat-storing cells in fibrogenesis
Semin Liver Dis
(1990)
Connective tissue metabolism and hepatic fibrosis
Semin Liver Dis
(1990)
Hepatocytes (hepatic parenchymal cells) produce a major part of liver collagen in vivo
Biochem Int
(1984)
Hepatocyte collagen production in vivo in normal rats
J Clin Invest
(1986)
Increased production of colagen in vivo by hepatocytes and nonparenchymal cells in rats with carbon tetrachloride-induced hepatic fibrosis
Hepatology
(1988)
Regulation of collagen production in freshly isolated cell populations from normal and cirrhotic rat liver: effect of lactate
Hepatology
(1991)
Minor contribution of hepatocytes to collagen production in normal and early fibrotic rat livers
Hepatology
(1991)
In situ hybridization for procollagen types I, III and IV mRNA in normal and fibrotic rat liver: evidence for predominant expression in nonparenchymal liver cells
Hepatology
(1989)
Cellular localization of laminin gene transcripts in normal and fibrotic human liver
Am J Pathol
(1989)
Transforming growth factor-β1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver
Lab Invest
(1990)
Cellular distribution of transforming growth factor β1 and procollagens types I, III and IV transcripts in carbon tetrachloride-induced rat liver fibrosis
J Clin Invest
(1990)
Albumin and collagen mRNA expression in normal and analbuminemic rodent liver: analysis by in situ hybridization using biotinylated probes
J Histochem Cytochem
(1990)
Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo
J Clin Invest
(1990)
Cited by (47)
Cellular Sources of Extracellular Matrix in Hepatic Fibrosis
2008, Clinics in Liver DiseaseCitation Excerpt :This process, characterized by the loss of typical SEC fenestrations and the formation of an organized basement membrane in the space of Disse, has been recognized as one of the hallmarks of liver fibrosis since it was first described in 1963.54 The literature is unclear on the relative contributions of HSCs and SECs to this process, but various techniques have shown that SECs secrete significant amounts of the components required for an organized basement membrane, including collagen IV, laminin, entactin, and perlecan.8,26,43,55–60 SECs seem to be the major perisinusoidal source of perlecan, a large and complex heparan sulfate proteoglycan that binds other matrix components, including fibronectin.43,61
Role for Hedgehog signaling in hepatic stellate cell activation and viability
2005, Laboratory InvestigationMolecular aspects of medicine: From experimental to clinical hepatology
2004, Molecular Aspects of MedicineMechanisms controlling early development of the liver
2003, Mechanisms of Development
Copyright © 1993 Published by Elsevier Ireland Ltd.