Rapid PublicationAnalysis of the hepatitis C virus genome in patients with anti-LKM-1 autoantibodies
References (7)
- et al.
Type 2 autoimmune hepatitis and hepatitis C virus infection
Lancet
(1990) Autoimmune hepatitis: the lesson of the discovery of hepatitis C virus
J Hepatol
(1993)- et al.
Genotypes of hepatitis C virus in Italian patients with chronic hepatitis C
J Hepatol Comm
(1994)
Cited by (32)
Autoantibodies in Autoimmune Liver Disease
2005, Advances in Clinical ChemistryCitation Excerpt :Antibodies to LKM1 are extremely rare in North American patients with chronic hepatitis C [13, 88] and this rarity may reflect differences in the indigenous virus or the genetic susceptibility of the host [87]. Studies in Germany [89] and Italy [90] have not found an association between structural changes within the viral genome and the presence of anti‐LKM1 and a host factor for anti‐LKM1 expression has been implicated. Patients with autoimmune hepatitis and anti‐LKM1 from Germany have DRB1*07 more frequently than seronegative white North American patients with autoimmune hepatitis and normal subjects [91].
Diagnosis and treatment of autoimmune hepatitis
2002, HepatologyCurrent concepts in the diagnosis, pathogenesis, and treatment of autoimmune hepatitis
2001, Mayo Clinic ProceedingsCitation Excerpt :This molecular mimicry may result in cross-reacting antibodies in some patients. Analyses of the viral genomic sequences in patients with and without anti-LKM1 have not indicated a virus-specific basis for the autoantibodies, and a host-specific genetic predisposition for autoantibody expression is likely.71,72 Antibodies to liver cytosol type 1 (anti-LC1) were originally described in uninfected patients with anti-LKM1, and they were considered adjunctive markers of the disease that reinforced the diagnosis of type 2 autoimmune hepatitis.73
Autoantibodies in liver disease
2001, GastroenterologyCitation Excerpt :Homologies exist between P450 IID6 and the genomes of the hepatitis C virus and herpes simplex type 1 virus.63 Consequently, anti-LKM1 can be found in these infections.107-111 Reactivities associated with chronic hepatitis C infection are usually against diverse epitopes, and epitope screening can distinguish the antibody subtypes.102,110,112,113
Viral genotypes as determinants of autoimmune expression in chronic hepatitis C
1999, Mayo Clinic ProceedingsBiology of the hepatitis C virus: Clinical implications
1997, Revue de Medecine Interne