Liver apoptosis
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Cited by (110)
Insulin resistance enhances binge ethanol-induced liver injury through promoting oxidative stress and up-regulation CYP2E1
2022, Life SciencesCitation Excerpt :The present study confirmed that IR could significantly sensitize the liver injury and inflammation response induced by ethanol. Apoptosis as one kind of cell deaths is characterized by special morphological and biochemical features such as apoptotic body [64]. It has been described that apoptosis cells were found in liver in the ALD model, and there is a significant correlation between apoptosis and liver injury [13].
Free fatty acid-induced miR-181a-5p stimulates apoptosis by targeting XIAP and Bcl2 in hepatic cells
2022, Life SciencesCitation Excerpt :Like other cells, apoptosis normally occurs in liver during development and in the renewal of hepatocytes. However, apoptosis can also be initiated in various other conditions, such as, viral infections, immunological, malignant and drug-induced liver disease [6]. Cytokeratin-18 fragments produced by caspase-3 were found in the NASH patients indicating enhanced apoptosis in these patients [7,8].
The intrinsic apoptotic pathway lies upstream of oxidative stress in multiple organs
2020, Free Radical Biology and MedicineCitation Excerpt :However, increased generation of RS and/or reduced antioxidant capacity can give rise to oxidative stress and subsequently damages proteins, lipids and DNA. BAX is a pro-apoptotic protein involved in the intrinsic apoptotic pathway in a wide variety of tissues, including the brain, heart, liver, and kidney [18–21]. Insertion of BAX into the outer mitochondrial membrane triggers the release of cytochrome c from the mitochondrial intermembrane space into the cytosol where it induces formation of the apoptosome and subsequent activation of executioner caspases such as caspase-3 (CASP3) [22].
Apoptotic gene expression profiles and DNA damage levels in rat liver treated with perfluorooctane sulfonate and protective role of curcumin
2017, International Journal of Biological MacromoleculesDietary fish oil protects against Gentamicin, Cisplatin, Uranyl Nitrate, and Nitric oxide donor/metabolite-induced nephrotoxicity and oxidative damage in rat kidney
2016, Fish and Fish Oil in Health and Disease PreventionHepatotoxicity of Herbal Preparations
2012, Zakim and Boyer's Hepatology