Synthesis and Surface Expression of ICAM-1 in Polymorphonuclear Neutrophilic Leukocytes in Normal Subiects and during Inflammatory Disease
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Cited by (22)
ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia
2016, BloodCitation Excerpt :With respect to neutrophils, ICAM-1 is generally absent or expressed at very low levels on circulating blood cells in humans and mice,15-18 although elevated levels have been reported in a limited number of clinical and experimental scenarios. For example, ICAM-1 has been detected on blood and peritoneal neutrophils in patients with bacterial peritonitis,19 on blood and nasopharyngeal aspirated neutrophils in infants with respiratory syncytial virus,20 on blood neutrophils after low-dose intravenous endotoxin,21 and on blood and bronchoalveolar lavage neutrophils from septic and sarcoidosis patients.22 In animal models, immunization of mice with Pseudomonas aeruginosa can also upregulate neutrophil ICAM-1 in vivo,18 and neutrophil reverse transendothelial cell migration has been associated with increased neutrophil ICAM-1 expression in vitro and in vivo with respect to human and mouse neutrophils.17,23
Cloning, sequencing and analysis of cDNA encoding bovine intercellular adhesion molecule-1 (ICAM-1)
1997, Veterinary Immunology and ImmunopathologyICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis
2020, Journal of Leukocyte Biology
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Dr. Gustav J. Dobos, Department of Nephrology, University Hospital Freiburg, Hugstetter Straβe 55, 79106 Freiburg, Germany