Progress in Neuro-Psychopharmacology and Biological Psychiatry
BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures
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Cited by (28)
High expression of Piezo1 induces senescence in chondrocytes through calcium ions accumulation
2022, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Yoda1 is a Piezo1-specific activator capable of activating Piezo1 channels in vitro and in vivo [19]. BAPTA-AM is an intracellular Ca2+ chelator that acts as a Ca2+ sponge to control intracellular Ca2+ concentration [20]. At last, Yoda1 and BAPTA-AM were further utilized to confirm the role of Piezo1 in mediating the chondrocytes senescence.
Intracellular second messengers mediate stress inducible hormesis and Programmed Cell Death: A review
2019, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :Experiments using these agents are consistent with the concept that increases in calcium can induce apoptosis in cultured cells such as B lymphoma and hepatic stellate [181–183]. Alternatively, cell permeable calcium chelators like BAPTA-AM can reduce stress mediated increases in calcium and serve to delay or inhibit cell death [184]. As expected calcium ionophores and chelators were also able to modulate other calcium dependent processes including many of the effects of insulin [185,186].
ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis
2016, Archives of Biochemistry and BiophysicsCitation Excerpt :These effects could be inhibited by 4-PBA, a chemical chaperone reported to relieve ER stress, and be augmented by TG treatment (Fig. 3D). To further address the role of Ca++ in ATO-mediated cell death, we used a cell permeable calcium chelator, BAPTA-AM [30]. Our results demonstrated that pretreatment of BAPTA-AM significantly blocked ATO-induced cell death in the ATF4+/+ MEFs (Fig. 3E).
Zinc oxide nanoparticles induce lipoxygenase-mediated apoptosis and necrosis in human neuroblastoma SH-SY5Y cells
2015, Neurochemistry InternationalCitation Excerpt :Accordingly, the increase in intracellular free zinc ion could also disturb intracellular calcium homeostasis. Previously, we demonstrated that esculetin, a lipoxygenase (LOX) inhibitor, attenuated neuronal injury mediated by the intracellular calcium chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid-acetoxymethyl ester (BAPTA/AM) (Wie et al., 2001). Here, a decline in intracellular free calcium, as well as elevation of intracellular calcium, levels resulted in a delayed and cycloheximide-sensitive neurotoxicity; however, transmission electron microscopy (TEM) findings showed necrotic injury and swelling or loss of the neuronal cell body and organelles in murine cortical cultures.
Tocotrienols in health and disease: The other half of the natural vitamin E family
2007, Molecular Aspects of Medicine