Hepatitis B virus genome variability and disease progression: the impact of pre-core mutants and HBV genotypes
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2023, Manson's Tropical Diseases, Fourth EditionNovel hepatitis B virus reverse transcriptase mutations in patients with sustained viremia despite long-term tenofovir treatment
2022, Journal of Clinical VirologyCitation Excerpt :In 2020, we also detected a small population of around 20% carrying both mutations in the spacer region and an 8 nucleotide deletion in the X protein leading to a nonsense frame and truncation of the X protein in the C-terminal Zinc finger motif. Mutation accumulation analyzed in the clones revealed a mutation rate of 3.1 × 10−4 substitutions/site/year (Supplementary Figure 3), similar to what has been shown previously [15]. Patient 2, a 57-year old male born in Denmark, was diagnosed with human immunodeficiency virus (HIV) and HBeAg positive CHB (genotype A) in 1996, with presumed sexual transmission.
Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA
2021, Journal of Biological ChemistryAcute and Chronic Hepatitis
2020, Pediatric Gastrointestinal and Liver Disease, Sixth Edition
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