Original articleHelicobacter pylori eradication improves pre-existing reflux esophagitis in patients with duodenal ulcer disease
Section snippets
Patients
We screened 1484 consecutive patients with a peptic ulcer who visited the outpatient clinic of Nippon Kokan Fukuyama Hospital from June 1995 to March 2003. There were 173 women and 1311 men, with a mean age of 48.9 years (range, 16–83 yr). These patients were mostly male factory workers at JFE Steel Corporation, West Japan Works, Fukuyama, Japan. A total of 779 patients had a gastric ulcer, 625 patients had a duodenal ulcer, and 80 patients had both. Among them, we enrolled 162 patients (10.9%)
Results
Six patients were dropped from the study because of an adverse drug reaction (diarrhea in 1 patient) or failure to complete the follow-up evaluation (5 patients). A total of 156 patients completed eradication therapy. H. pylori infection was cured in 120 (76.9%) of the 156 patients. The background characteristics of these 156 patients are provided in Table 1.
After eradication therapy, an improvement of reflux esophagitis was observed endoscopically in 87 (55.8%, 95% confidence interval [CI] =
Discussion
In the present study, we showed endoscopic improvement or disappearance in pre-existing reflux esophagitis in a significant portion of the 156 peptic ulcer patients evaluated systematically after therapy for eradication of H. pylori. Although an improvement of reflux symptoms after H. pylori eradication has been reported by several investigators,15, 16, 17 we have shown further endoscopic improvement of esophagitis. Low body mass index, cured H. pylori infection, the absence of hiatal hernia,
Acknowledgements
The authors thank Drs. Tetsuji Okuno, Tsuyoshi Okamoto, Fumihiro Hamada, Hidehiko Ishioka, Hiromi Hamamoto, and Shinitirou Hori, and Masako Kataoka, Youko Hakoda, Yoshimi Itoh, Rumiko Suzuki, and Hideaki Inoue (Nippon Kokan Fukuyama Hospital) for their support; and Dr. William R. Brown (Denver Health Medical Center, Denver, Colorado) for his assistance in the preparation of this manuscript.
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