Original articleClinical Predictors for Hepatocellular Carcinoma in Patients With Primary Biliary Cirrhosis
Section snippets
Study Design and Population
We conducted a case-control study using patients with PBC who were seen at the Mayo Clinic from 1976 to 2002. Case subjects were patients who had a diagnosis of PBC and HCC. Control subjects were patients who had a diagnosis of PBC but did not have HCC during their follow-up examination. The diagnosis of PBC was established by the following: (1) laboratory abnormalities consistent with chronic cholestatic liver disease for at least 6 months, (2) serum alkaline phosphatase level of at least 1.5
Results
The follow-up time defined as the time difference between the PBC diagnosis at the Mayo Clinic and HCC diagnosis (or closest visit in controls) was not significantly different between the groups (93 ± 18 vs 66 ± 10 mo, P = .194). For controlling the unmatched difference in follow-up time, the follow-up time was taken into account in the analyses.
The clinical characteristics of the study population are summarized in Table 2. As shown in Table 2, age, sex, history of blood transfusion, current
Discussion
In this study, we conducted a case-control study using patients with PBC who were seen at the Mayo Clinic from 1976 to 2002 and showed that older age, male sex, history of blood transfusion, and the presence of portal hypertension were associated significantly with increased odds of HCC among patients with PBC even after controlling for the other factors and the length of follow-up time. The model with male sex, age, history of blood transfusion, current smoking, and the presence of ascites
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Supported in part by the Miles and Shirley Fiterman Center for Digestive Diseases at the Mayo Clinic, Rochester, MN.