Original article—alimentary tractRisk of Developing Proximal Versus Distal Colorectal Cancer After a Negative Colonoscopy: A Population-Based Study
Section snippets
Data Sources
Four data sources were used in this study.
First, the Canadian Institute for Health Information—Discharge Abstract Database (CIHI-DAD) contains information about all diagnoses and procedures for patients discharged from acute care hospitals and hospital-based, same-day surgery units for residents of Ontario since April 1, 1988. All diagnostic codes are recorded according to the International Classification of Diseases, 9th revision, clinical modification (ICD-9-CM)12 from April 1, 1988, to March
Results
From January 1, 1992, to December 31, 1997, we identified 110,402 individuals who had a negative complete colonoscopy. In the remaining Ontario population, 2,859,087 met the exclusion criteria and did not have a colonoscopy (controls). Table 1 shows the characteristics of the 2 groups. Compared with the Ontario population (controls), in the negative complete colonoscopy cohort the proportion of women was slightly greater (55.2% vs 52.1%), and the age distribution was somewhat older.
During the
Discussion
We report here that after a negative complete colonoscopy there is a sustained reduction in incident CRC overall and incident distal CRC for up to 14 years after the procedure. In the proximal colon, however, the reduction in incidence after negative complete colonoscopy differed in magnitude and timing. The reduction in incidence was observed in about half of the 14 follow-up years, and for the most part occurred after 7 years of follow-up evaluation.
It is only recently that CRC incidence
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The authors disclose no conflicts.