Original article—alimentary tractHigh-Definition Colonoscopy Detects Colorectal Polyps at a Higher Rate Than Standard White-Light Colonoscopy
Section snippets
Data Collection
The computerized clinical and endoscopic charts database of the Mayo Clinic Jacksonville served as a data source for this study, which was approved by the Mayo Clinic Institutional Review Board. We reviewed the computerized charts of patients who underwent colonoscopies between September 2006 and December 2007 in the outpatient general practice setting. Patient information was collected regarding age, sex, race, family history of colon cancer, history of polyps, and aspirin use. Colonoscopy
Results
Table 1 provides a summary of patient, colonoscopy, and endoscopist characteristics for both the 1204 HDWL and 1226 SDWL colonoscopy patients. Similar patient characteristics for the HDWL and SDWL groups included age, sex, race, family history of colon cancer, history of polyps, bowel preparation, endoscopist training, and the presence of a fellow. Aspirin use was slightly more common in patients in the HDWL group. The indication for procedure was more often “screening” in the HDWL group, and
Discussion
Our study showed that the use of high-definition colonoscopes was associated with a higher adenoma detection rate in comparison with standard-definition colonoscopes. This higher rate was most apparent for smaller adenomas (<10 mm) and adenomas in the left colon.
Although detection rates of smaller adenomas were more significant for diminutive (1–5 mm) adenomas known to be of the least risk of advanced of histology (3.9% difference) as compared with adenomas of 6 to 9 mm (2.5% difference), these
Acknowledgments
The authors wish to thank Ms Nancy Diehl for statistical assistance, Ms Katherine Purcell for manuscript editorial assistance, and all the fellows and staff of the Gastroenterology and Hepatology Division of the Mayo Clinic Jacksonville for contribution of data to this study.
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Conflicts of interest The authors disclose the following: Dr Wallace receives research funding from Olympus and Fujinon, but does not receive any funds from the company that produces the products evaluated in this study. The remaining authors disclose no conflicts. Mayo Clinic does not endorse the products mentioned in this article.
Funding The statistical analysis was funded by support for Fellowship Research provided by Fujinon, Inc, and TAP/Takeda Pharmaceuticals, Inc.