Original articleAlimentary tractTrends in Overall and Cause-Specific Mortality Among Patients With Inflammatory Bowel Disease From 1982 to 2010
Section snippets
Study Population
A national cohort of all individuals alive and residing in Denmark between 1982 and 2010 (on average 5.3 million) was established by use of the Danish Civil Registration System, a national demographic register with continuously updated information on sex, place of birth, address, marital status, and dates of immigration, emigration, and death for all Danish citizens.6 Coding of information in Danish registers and linkage between registers rely on a unique 10-digit personal identification number
Results
From 1982 to 2010, 36,080 individuals were diagnosed with UC (median age, 45.2 years; 53% women), and 15,361 individuals were diagnosed with CD (median age, 36.3 years; 57% women). These patients were matched with 2,858,096 controls from the general population. Demographic characteristics appear in Table 1.
Discussion
This nationwide Danish cohort study of 51,441 patients with IBD and 2,858,096 matched controls showed an overall long-term mortality (10+ years), which was 10% increased among patients with UC and 50% increased among patients with CD. A significant relative decrease in mortality from 1982 to 1989 and 2000 to 2010 was observed among patients with UC, primarily because of a relative decrease in mortality from gastrointestinal disorders, colorectal cancer, and suicide. Overall and cause-specific
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2022, Journal of Psychosomatic ResearchCitation Excerpt :These findings highlight the importance of focusing on suicide risk factors in women with IBD or CD. In a literature review, Jess et al. reported that UC with a disease duration of less than one year had a higher risk of suicide (HR 2.05; 95% CI, 1.40–2.99), and CD with a 2–4 year duration tended to have a higher risk of death from suicide (HR 1.45; 95% CI, 0.96–2.20) [29]. However, Jussila and colleagues found that more suicides were observed within 3–9.9 years of the disease course for both UC (SMR 1.28; 95% CI, 0.87–1.83) and CD (SMR 1.89; 95% CI, 0.98–3.30) [31].
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Conflicts of interest The authors disclose no conflicts.
Funding Dr Tine Jess is supported by a Female Research Leader Grant (no. 09-066323) from the Danish Council of Independent Research. The project was also supported by the Danish Cancer Society (grant no. R40-A1737-11-S2).