Original articleAlimentary tract: EditorialQuantitation of Hemoglobin Improves Fecal Immunochemical Tests for Noninvasive Screening
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Cited by (14)
Faecal haemoglobin: Measurement, applications, and future potential
2023, Best Practice and Research: Clinical GastroenterologyStool Testing for Colorectal Cancer Screening
2015, GastroenterologyCitation Excerpt :Also quantitative testing allows the opportunity to select a test with a hemoglobin cut off that best matches available endoscopic resources. Given these types of advantages, there is growing enthusiasm for the adoption of quantitative FIT over qualitative tests.27 Quantitative FIT affords the opportunity to set the test to a desired hemoglobin threshold that maximizes detection and minimizes false positive rates.
Rate of Detection of Advanced Neoplasms in Proximal Colon by Simulated Sigmoidoscopy vs Fecal Immunochemical Tests
2014, Clinical Gastroenterology and HepatologyCitation Excerpt :Second, because of the nature of this post hoc analysis, long-term diagnostic yield of both sigmoidoscopy and FIT cannot be established because participation in each screening strategy could not be evaluated and data on detection rate were limited to the first screening round. This latter circumstance may contribute to underestimate the effectiveness of FIT mainly, a test repeatedly performed in a program of repeated screening episodes over time.25 In conclusion, results of this study indicate that sigmoidoscopy and FIT may have similar limitations in detecting APN, a circumstance that largely depends on individuals' characteristics.
Risk stratification for advanced colorectal neoplasia according to fecal hemoglobin concentration in a colorectal cancer screening program
2014, GastroenterologyCitation Excerpt :More importantly, a combination of this variable with demographic characteristics (ie, sex and age) allows stratification of FIT-positive individuals into 3 risk categories with different probabilities of presenting with an advanced colorectal neoplasia. The quantitative nature of FITs represents a big step forward in colorectal cancer prevention31 and probably will require an adjustment of the current approach to the screening policy. FIT is a recognized screening strategy based on its capacity to discriminate between individuals with colorectal neoplasms and those without such lesions.28,29,32–35
Tests and investigations for colorectal cancer screening
2014, Clinical BiochemistryCitation Excerpt :The EWG’s major goal was to forge an international consensus agreement on FIT nomenclature, standardisation/calibration, performance characteristics, and reporting units and the reporting of sample stability. The EWG has published a number of research papers [117–125] and its recommendations and activities are available on the WEO website (http://www.worldendo.org/weo-crcsc-expert-working-group-fit-for-screening.html). The following section on FIT performance (e.g. uptake of screening, clinical outcomes, cost-effectiveness) outlines some of the evidence that supports the use of quantitative FIT for population-based cancer screening.
The utility of faecal and urine biomarkers for small bowel diseases
2021, Current Opinion in Gastroenterology
Conflicts of interest This author discloses the following: Callum Fraser has served as a consultant for Immunostics, Inc, and Mode Diagnostics; has received research support from Mast Diagnostics and Eiken Chemical Co; and has received travel funding from Alpha Labs Ltd. The remaining authors disclose no conflicts.