EditorialEosinophilic Esophagitis and Proton Pump–Responsive Esophageal Eosinophilia: What Is in a Name?
References (24)
- et al.
Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults
Clin Gastroenterol Hepatol
(2011) - et al.
Markers of eosinophilic inflammation for diagnosis of eosinophilic esophagitis and proton pump inhibitor–responsive esophageal eosinophilia: a prospective study
Clin Gastroenterol Hepatol
(2014) - et al.
Involvement of mast cells in eosinophilic esophagitis
J Allergy Clin Immunol
(2010) - et al.
Increased numbers of eosinophils, rather than only etiology, predict histologic changes in patients with esophageal eosinophilia
Clin Gastroenterol Hepatol
(2012) - et al.
Correlation of ALOX15 expression with eosinophilic or reflux esophagitis in a cohort of pediatric patients with esophageal eosinophilia
Hum Pathol
(2014) - et al.
Gastroesophageal reflux might cause esophagitis through a cytokine-mediated mechanism rather than caustic acid injury
Gastroenterology
(2009) - et al.
Molecular diagnosis of eosinophilic esophagitis by gene expression profiling
Gastroenterology
(2013) Diagnosis and management of eosinophilic esophagitis
Clin Gastroenterol Hepatol
(2012)- et al.
Results of ambulatory pH monitoring do not reliably predict response to therapy in patients with eosinophilic esophagitis
Aliment Pharmacol Ther
(2012) - et al.
Clinical and endoscopic characteristics do not reliably differentiate PPI-responsive esophageal eosinophilia and eosinophilic esophagitis in patients undergoing upper endoscopy: a prospective cohort study
Am J Gastroenterol
(2013)
The outcome of patients with esophageal eosinophilic infiltration after an eight-week trial of a proton pump inhibitor
Aliment Pharmacol Ther
Treatment with proton pump inhibitors is effective in a majority of adults patients with eosinophilic esophagitis
Gastroenterology
Cited by (15)
Dual response to dietary/topical steroid and proton pump inhibitor therapy in adult patients with eosinophilic esophagitis
2016, Journal of Allergy and Clinical ImmunologyDiagnostic approach to eosinophilic oesophagitis: Pearls and pitfalls
2015, Best Practice and Research: Clinical GastroenterologyCitation Excerpt :PPI-REE describes patients with clinical and histologic features of EoE but who respond histologically and clinically to a PPI therapy [53,54]. The pathogenesis of these patients remains poorly understood [6,53]. It is currently unknown if PPI-REE and EoE are distinct diseases [53].
Interactions between gastro-oesophageal reflux disease and eosinophilic oesophagitis
2015, Best Practice and Research: Clinical GastroenterologyCitation Excerpt :Other recent studies have also shown the ability of PPI therapy to nearly entirely reverse gene expression associated with PPI-REE, particularly that associated with classic features of allergic inflammation [39]. As such, there is concern whether PPI-REE and EoE should be considered different diseases, when they share genetic, phenotypic and mechanistic features [40]. It might be preferable, accordingly, to approach EoE as a disease in which use of PPI therapy is the first step in treatment and diet and steroids represent step up therapy.
Eosinophilic Esophagitis, Then and Now: A Review
2023, Current Pediatrics ReportsProton pump inhibitor-responsive esophageal eosinophilia: Still a valid diagnosis?
2017, Current Opinion in GastroenterologyOesophageal narrowing on barium oesophagram is more common in adult patients with eosinophilic oesophagitis than PPI-responsive oesophageal eosinophilia
2016, Alimentary Pharmacology and Therapeutics
Conflicts of interest The author discloses no conflicts.