Original articleAlimentary tractIn Vitro Fertilization in Women With Inflammatory Bowel Disease Is as Successful as in Women From the General Infertility Population
Section snippets
Study Population
We identified 8684 female patients with IBD who were seen between 1998 and 2011 for possible inclusion in this matched retrospective cohort study from medical records of the gastrointestinal divisions of Beth Israel Deaconess Medical Center (Boston, MA; n = 4028) and Brigham and Women’s Hospital (Boston, MA; n = 4656). We also identified all women who underwent their first fresh, nondonor, nongestational carrier IVF cycle at Boston IVF (an affiliate of Beth Israel Deaconess Medical Center;
Results
We identified 132 patients with IBD who underwent IVF and 470 women without IBD who fulfilled matching criteria. Eleven of the women with IBD were excluded because the diagnosis of IBD could not be confirmed as having preceded the first IVF cycle. Seventy-one patients had UC, and 49 patients had CD; 1 patient had IBD-unclassified. The disease characteristics of the CD and UC patients are described in Tables 1 and 2, respectively.
Patients with CD received a diagnosis at a median of 10.3 years
Discussion
We evaluated the success of IVF in both medically and surgically treated IBD patients. Our results suggest that women with IBD have similar rates of pregnancy and live births after IVF compared with women without IBD. The cumulative live birth rates were similar to previously reported rates of 51% to 74% after 6 cycles of IVF.13, 24, 25 The cumulative live birth rates in the UC cohort were somewhat higher than in the CD and non-IBD populations, although this difference did not reach statistical
References (25)
- et al.
Age-related differences in presentation and course of inflammatory bowel disease: an update on the population-based literature
J Crohns Colitis
(2014) - et al.
Fertility and pregnancy in inflammatory bowel disease
Int J Gynaecol Obstet
(1997) - et al.
Increased risk of preterm birth for women with inflammatory bowel disease
Gastroenterology
(1990) - et al.
Ulcerative colitis: female fecundity before diagnosis, during disease, and after surgery compared with a population sample
Gastroenterology
(2002) - et al.
Multivariate analysis of factors affecting probability of pregnancy and live birth with in vitro fertilization: an analysis of the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System
Fertil Steril
(2010) - et al.
Factors affecting the cumulative live birth rate in IVF cycles. Retrospective analysis of a 1001 couples cohort
Gynecol Obstet Fertil
(2012) - et al.
The influence of female and male body mass index on live births after assisted reproductive technology treatment: a nationwide register-based cohort study
Fertil Steril
(2013) - et al.
Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis
Reprod Biomed Online
(2011) - et al.
Future in vitro fertilization pregnancy potential of women with variably elevated day 3 follicle-stimulating hormone levels
Fertil Steril
(1996) - et al.
Recent cigarette smoking and assisted reproductive technologies outcome
Fertil Steril
(2010)
The cumulative probability of live born multiples after in vitro fertilization: a cohort study of more than 10,000 women
Fertil Steril
Systematic review: fertility in non-surgically treated inflammatory bowel disease
Aliment Pharmacol Ther
Cited by (28)
Women's Health and Ulcerative Colitis
2020, Gastroenterology Clinics of North AmericaCitation Excerpt :Rates of infertility, defined as the inability to conceive within 1 year of having unprotected intercourse, in people with ulcerative colitis are overall similar to the general population. For those females with ulcerative colitis who are unable to conceive, studies suggest that infertility treatments (such as in vitro fertilization) are successful at similar rates to the general population,34 including in those patients with a history of IPAA.35 The care of pregnant patients with ulcerative colitis is complex and best achieved by a multidisciplinary approach involving gastroenterology providers and maternal and fetal medicine specialists.
Inflammatory bowel diseases and reproductive health
2016, Pharmacological ReportsCitation Excerpt :There is only little data regarding the use of IVF among women with IBD, primarily in those who were surgically treated by using one of the three types of operations i.e. ileostomy, colostomy, or IPAA [24]. In a recent matched retrospective cohort study, Oza et al. evaluated the success of IVF in IBD patients compared with the general (non-IBD) IVF population [24]. In the same cohort, Pabby et al. examined the success of IVF among women with UC post-IPAA [25].
Local and systemic factors and implantation: What is the evidence?
2016, Fertility and SterilityCitation Excerpt :It is unclear whether this effect manifests itself as diminished ovarian reserve or an increased risk for implantation failure. To better characterize this association, Oza et al. (151) published a retrospective cohort study comparing IVF outcomes in 120 patients with IBD with 470 age-matched controls. Although implantation rate was not calculated, the mean number of embryos transferred (two) was the same for each group.
Infertility in Inflammatory Bowel Diseases: A Cause for Hope?
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Conflicts of interest These authors disclose the following: Adam Cheifetz has performed consulting and/or research for Janssen, AbbVie, Takeda, and Pfizer; and Alan Penzias has served on the advisory board (with compensation) for OvaScience and Nora Therapeutics, has served as a consultant for ReproSource, Inc, and has served on the speakers bureau for Ferring Pharmaceuticals. The remaining authors disclose no conflicts.
Funding Supported by Harvard Catalyst, The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health award UL1 TR001102) and financial contributions from Harvard University and its affiliated academic health care centers (M.H.).
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Authors share co-senior authorship.