Original Article: Clinical EndoscopyEvaluation of microvessels in colorectal tumors by narrow band imaging magnification
Section snippets
Lesions and colonoscopic observations
A total of 189 colorectal lesions from 163 patients who underwent endoscopic or surgical resection at Hiroshima University Hospital were analyzed. Each patient provided informed consent. Lesions were first detected by conventional views and then observed by magnified views with the NBI system. Two specialists with more than 10 years of experience in the field of colonoscopy performed the endoscopic observations in this study. The instruments used in this study were a magnifying videoendoscope
MVC and microvessel diameter as determined by immunohistochemistry
Immunohistologic features of microvessels in HP lesions and sm-m are shown in Figure 3. Endothelial cells were stained with an anti-CD34 monoclonal antibody. Microvessel diameter was small and of homogeneous size, and MVC was low in HP lesions. Microvessel diameter was of uneven size (small and large microvessels mixed together), and MVC was greater in sm-m lesions than in other lesions.
MVC ranged from 5 to 52, with a mean ± SD of 19.5 ± 8.4 μm (median, 20 μm). Therefore, lesions were
Discussion
Magnifying endoscopy provides details of the surface of the GI tract, which has made it possible to examine the pit pattern of colorectal tumors, even during routine colonoscopic examination by using dye spraying, such as indigo carmine.14, 15, 16, 17, 18, 19 The pit pattern classification of colorectal tumors (type I-V pit pattern), based on stereomicroscopy, as proposed by Kudo et al,18, 19 is reported to be useful for evaluating the histologic features of tumors. Assessment of pit pattern is
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