Reviews and feature articleCeliac disease
Section snippets
Epidemiology
CD was once considered a rare condition characterized predominately by intestinal symptoms that led to a malabsorption syndrome and stunted growth in young children of European ancestry. However, it is now appreciated that CD has a worldwide and increasing incidence among persons of various ethnic groups and among both adults and children.15, 16, 17, 18
Numerous studies in which serologic screening was performed among the general population indicate that CD has a prevalence of nearly 1% among
Conclusions
Over the decades since the initial description of CD, there has been a major increase in the awareness of the disease among the general population. Although generally underdiagnosed, CD appears to have an increasing prevalence worldwide. The introduction of wheat-based products into societies throughout the globe might contribute to the trend; however, other environmental factors that allow for patients with a predisposing genetic background to have the disease are only partially understood.
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Series editors: Donald Y. M. Leung, MD, PhD, and Dennis K. Ledford, MD