Research ArticleFasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids
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Graphical abstract
Abbreviations
AT
Adipose tissue
FA(s)
fatty acid(s)
TG
triacylglycerol
CGI-58
comparative gene identification-58
ATGL
Adipose triglyceride lipase
CGI-58-ATko
AT-selective ablation of CGI-58
ATGL-ATko
AT-specific deficiency of ATGL
LD
lipid droplet
NAFLD
nonalcoholic fatty liver disease
NLSD
Neutral lipid storage disease
PPARα
peroxisome proliferator-activated receptor alpha
CREBH
cAMP-responsive element binding protein, hepatocyte specific
G0S2
G0/G1 Switch Gene 2
FGF21
fibroblast growth factor 21
PGC-1α
PPARgamma co-activator-1alpha
HNF4α
hepatocyte nuclear factor 4alpha
PEPCK
Phosphoenolpyruvate carboxykinase
G6Pase
Glucose-6-phosphatase
ER
endoplasmic reticulum
Keywords
Hepatic steatosis
G0/G1 switch gene 2
Fibroblast growth factor 21
CGI-58
ATGL
Lipolysis
PPARα
CREBH
Obesity
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© 2015 European Association for the Study of the Liver. Published by Elsevier B.V.