Research ArticleMultivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis
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Graphical abstract
Abbreviations
ALF
acute liver failure
ACLF
acute on chronic liver failure
CLIF-SOFA
chronic liver failure sequential organ failure assessment
CPS
Child-Pugh Score
CPMG
Carr-Purcell-Meiboom-Gill
CV-ANOVA
cross-validated analysis of variance
ESI
electrospray ionisation
GC-MS
gas chromatography mass spectrometry
INR
international normalised ratio
LPC
lysophosphatidylcholine
MELD
model for end-stage liver disease
MHE
minimal hepatic encephalopathy
MS
mass spectrometry
NMR
nuclear magnetic resonance
PC
phosphocholine
PCA
principal components analysis
PLSDA
partial least squares discriminant analysis
OPLS
orthogonal projection least squares
STOCSY
statistical correlation spectroscopy
TOF
time-of-flight
UPLC
ultra-performance liquid chromatography
UKELD
United Kingdom end-stage liver disease
Keywords
Metabonomics
Metabolomics
Metabolic profiling
Personalised medicine
Outcome prediction
Acute on chronic liver failure
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These authors contributed equally to the work.
Copyright © 2016 European Association for the Study of the Liver. Published by Elsevier B.V.