Original ArticlePubertal Changes of Insulin Sensitivity, Acute Insulin Response, and β-Cell Function in Overweight Latino Youth
Section snippets
Methods
Participants were enrolled in the SOLAR (Study of Latino Adolescents at Risk) Diabetes Project at the University of Southern California. This study is an ongoing, longitudinal investigation exploring risk factors in a group of boys and girls at high risk for developing type 2 diabetes early in life. Data are collected for each participant annually. We have previously reported several findings from this cohort including a baseline cross-sectional analysis of puberty and a 1-year follow-up
Results
The baseline (visit 1) characteristics of the 253 participants in the SOLAR cohort are presented in the Table. At baseline, participants included 110 girls and 143 boys. The mean age at baseline was 11.1 ± 1.7 years, and analysis included an average of 3.2 ± 1.6 visits per participants for a total of 818 visits. The Table shows the number of observations per Tanner stage. For SI, there was a decrease from Tanner stages 1 through 3, after which boys increased in SI, and girls continued to
Discussion
The findings from this analysis indicate that the compensation to pubertal insulin resistance in obese Hispanic children was different by sex in the early stages of maturation, though the end result of a declining DI across all stages of puberty was consistent in boys and girls. For boys in early maturation, there was only a marginal improvement in AIR, despite progressive insulin resistance. After Tanner stage 3, SI improved, but AIR declined by more than would be predicted from the
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Supported by grants (R01 DK 59211 and M01 RR 00043), the American Diabetes Association, Mentor-Based Postdoctoral Fellowship (F31-DK081276 to C.T.-C. under the sponsorship of M.G.), and the USC Center for Transdisciplinary Research on Energetics and Cancer (U54 CA 116848). The authors declare no conflicts of interest.