Society of University SurgeonsChanges in GI hormones and their effect on gastric emptying and transit times after Roux-en-Y gastric bypass in rat model
Section snippets
Methods
Approval for the experiments was obtained from the Committee for the Humane Use of Animals at SUNY Upstate Medical University. Animal care was in accordance with guidelines established by the National Institutes of Health.
Body weight
Figure 2 shows the changes in BW at day 0 (before the operation) and at postoperative days 14, 28, and 90. The 3 groups had no difference in BW before the operation. During the first 7 postoperative days, all groups lost weight because of postoperative stress and an inadequate oral liquid intake. The rate of weight loss in the SO Obese was −8.2 ± 1.4 g per day, while the rate of BW loss in RYGB and PF was −14.3 ± 2.3 g per day and −11.6 ± 1.5 g per day, respectively. On day 7, chow was given
Discussion
The endocrine L cells secrete PYY in response to intraluminal nutrients. These cells are found in progressively higher gradient concentrations from the duodenum and jejunum, where PYY is released at relatively lower concentrations, to the terminal ileum and the colon, where PYY is secreted in high concentrations.25 PYY's biological function includes inhibiting food intake, decreasing GE, and slowing GI motility.18, 26 Ninety days after the operation, the SO Obese rats weighed more than before
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Presented at the 66th Annual Meeting of the Society of University Surgeons, Nashville, Tennessee, February 9-12, 2005.
Supported in part by grants from the Hendrick's Fund, American Society for Bariatric Surgery and American Diabetes Association. C.G.G. is supported, in part, by a postdoctoral grant from SUNY Upstate Medical University Hendrick's Fund #130230-52. Material support was provided via generous grants from Ethicon (Cincinnati, Ohio) and Boost-Plus from Mead Johnson (Evansville, Ind).